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Assay Detail

CHEMBL1675579

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Functional
Antiviral activity against Human cytomegalovirus Towne infected in human HFL after 10 to 12 days by plaque reduction assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human betaherpesvirus 5
Confidence 1 — Organism
Curated By Autocuration

Target

Human betaherpesvirus 5 (CHEMBL371)
Type ORGANISM
Organism Human betaherpesvirus 5

Publication

Establishment of a cell-based assay for screening of compounds inhibiting very early events in the cytomegalovirus replication cycle and characterization of a compound identified using the assay.
Fukui Y, Shindoh K, Yamamoto Y, Koyano S, Kosugi I, Yamaguchi T, Kurane I, Inoue N.
Antimicrob Agents Chemother (2008) 52 : 2420 -2427
PubMed 18458124 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.73 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182 GANCICLOVIR 4.0 1 5.85
CHEMBL1673059 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182 GANCICLOVIR EC50 = 1400.0 nM 5.85
CHEMBL1673059 EC50 = 2500.0 nM 5.60