Assay Detail
Binding
CHEMBL1675910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Enterobacter cloacae Beta-lactamase AmpC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1207337 | — | — | 1 | 7.21 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 5.75 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 4.92 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1207337 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL403 | SULBACTAM | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 136200.0 | nM | - |