Assay Detail
Binding
CHEMBL1675911
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Inhibition of Beta-lactamase TEM-1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.85 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.52 |
| CHEMBL1207337 | — | — | 1 | 7.26 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1207337 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL403 | SULBACTAM | IC50 | = | 1060.0 | nM | 5.97 |