Assay Detail
Functional
CHEMBL1676769
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Antiproliferative activity against human DG75 cells after 24 hrs Alamar blue assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DG-75 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 4.73 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672024 | — | — | 1 | 5.50 |
| CHEMBL1672025 | — | — | 1 | 5.10 |
| CHEMBL1672022 | — | — | 1 | 4.90 |
| CHEMBL1671870 | — | — | 1 | 4.90 |
| CHEMBL1164191 | — | — | 1 | 4.60 |
| CHEMBL1672023 | — | — | 1 | 4.60 |
| CHEMBL1672021 | — | — | 1 | 4.40 |
| CHEMBL1672014 | — | — | 1 | 4.30 |
| CHEMBL1672027 | — | — | 1 | 4.30 |
| CHEMBL1672016 | — | — | 1 | - |
| CHEMBL1672015 | — | — | 1 | - |
| CHEMBL1672017 | — | — | 1 | - |
| CHEMBL1672018 | — | — | 1 | - |
| CHEMBL1672019 | — | — | 1 | - |
| CHEMBL1165387 | — | — | 1 | - |
| CHEMBL1672026 | — | — | 1 | - |
| CHEMBL1165775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672024 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL1672025 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1672022 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL1671870 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL1164191 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1672023 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1672021 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL1672014 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL1672027 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL1672016 | — | EC50 | = | 398107.17 | nM | - |
| CHEMBL1672015 | — | EC50 | = | 251188.64 | nM | - |
| CHEMBL1672017 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL1672018 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL1672019 | — | EC50 | = | 199526.23 | nM | - |
| CHEMBL1165387 | — | EC50 | = | 398107.17 | nM | - |
| CHEMBL1672026 | — | EC50 | = | 125892.54 | nM | - |
| CHEMBL1165775 | — | EC50 | = | 5011872.34 | nM | - |