Assay Detail
Binding
CHEMBL1677255
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Inhibition of HCV 1a NS3/4A protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.79 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 8.96 |
| CHEMBL1241348 | FALDAPREVIR | 3.0 | 1 | 8.92 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1241348 | FALDAPREVIR | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 3.2 | nM | 8.49 |