Assay Detail
Functional
CHEMBL1677267
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Antiviral activity against HCV 1b infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.02 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241348 | FALDAPREVIR | 3.0 | 1 | 8.51 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 6.28 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241348 | FALDAPREVIR | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 540.0 | nM | 6.27 |