Assay Detail
Binding
CHEMBL1677688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B expressed in Escherichia coli assessed as tight binding affinity constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aspergillus fumigatus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
14-alpha sterol demethylase (CHEMBL1681624) ↗| Type | SINGLE PROTEIN |
| Organism | Neosartorya fumigata (Aspergillus fumigatus) |
Publication
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.00 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 7.51 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 7.14 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 6.99 |
| CHEMBL638 | VORICONAZOLE | 4.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL1397 | POSACONAZOLE | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL104 | CLOTRIMAZOLE | Kd | = | 103.0 | nM | 6.99 |
| CHEMBL638 | VORICONAZOLE | Kd | = | 429.0 | nM | 6.37 |