Assay Detail
Binding
CHEMBL1677802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.96 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672083 | — | — | 1 | 9.85 |
| CHEMBL3216716 | — | — | 1 | 9.72 |
| CHEMBL3216475 | — | — | 1 | 9.66 |
| CHEMBL3216476 | — | — | 1 | 9.48 |
| CHEMBL3216936 | — | — | 1 | 9.46 |
| CHEMBL1672091 | — | — | 1 | 9.40 |
| CHEMBL514774 | — | — | 1 | 9.32 |
| CHEMBL1672087 | — | — | 1 | 9.04 |
| CHEMBL1672086 | — | — | 1 | 9.00 |
| CHEMBL1672090 | — | — | 1 | 8.96 |
| CHEMBL1672085 | — | — | 1 | 8.11 |
| CHEMBL1672084 | — | — | 1 | 7.81 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672083 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3216716 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL3216475 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3216476 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL3216936 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL1672091 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL514774 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL1672087 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL1672086 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL1672090 | — | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL1672085 | — | Ki | = | 7.86 | nM | 8.11 |
| CHEMBL1672084 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL70 | MORPHINE | Ki | = | 217.0 | nM | 6.66 |