Assay Detail

CHEMBL1678189

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Binding

Inhibition of Hepatitis C virus subtype 1b NS3/4A protease

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 1b
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

Lenz O, Verbinnen T, Lin TI, Vijgen L, Cummings MD, Lindberg J, Berke JM, Dehertogh P, Fransen E, Scholliers A, Vermeiren K, Ivens T, Raboisson P, Edlund M, Storm S, Vrang L, de Kock H, Fanning GC, Simmen KA.
Antimicrob Agents Chemother (2010) 54 : 1878 -1887
PubMed 20176898 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.30	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL501849	SIMEPREVIR	4.0	1	9.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL501849	SIMEPREVIR	Ki	=	0.5	nM	9.30