Assay Detail
Functional
CHEMBL1678441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.98 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672234 | — | — | 1 | 7.00 |
| CHEMBL1672245 | — | — | 1 | 6.94 |
| CHEMBL1672244 | — | — | 1 | 6.44 |
| CHEMBL1909434 | — | — | 1 | 6.39 |
| CHEMBL1672243 | — | — | 1 | 6.37 |
| CHEMBL1672238 | — | — | 1 | 6.29 |
| CHEMBL1672241 | — | — | 1 | 6.25 |
| CHEMBL1672232 | — | — | 1 | 6.20 |
| CHEMBL1672233 | — | — | 1 | 6.07 |
| CHEMBL1672242 | — | — | 1 | 6.02 |
| CHEMBL1385271 | — | — | 1 | 6.01 |
| CHEMBL1909435 | — | — | 1 | 5.98 |
| CHEMBL1672237 | — | — | 1 | 5.95 |
| CHEMBL1373422 | — | — | 1 | 5.93 |
| CHEMBL1672236 | — | — | 1 | 5.88 |
| CHEMBL1672257 | — | — | 1 | 5.85 |
| CHEMBL1672256 | — | — | 1 | 5.85 |
| CHEMBL1509597 | — | — | 1 | 5.84 |
| CHEMBL1672240 | — | — | 1 | 5.79 |
| CHEMBL1672235 | — | — | 1 | 5.75 |
| CHEMBL1672239 | — | — | 1 | 5.68 |
| CHEMBL1909431 | — | — | 1 | 5.67 |
| CHEMBL1909433 | — | — | 1 | 5.66 |
| CHEMBL1672247 | — | — | 1 | 5.62 |
| CHEMBL1672246 | — | — | 1 | 5.37 |
| CHEMBL1909436 | — | — | 1 | 5.33 |
| CHEMBL507522 | — | — | 1 | 5.32 |
| CHEMBL1672231 | — | — | 1 | - |
| CHEMBL1672230 | — | — | 1 | - |
| CHEMBL1909430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672234 | — | EC50 | = | 99.5 | nM | 7.00 |
| CHEMBL1672245 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1672244 | — | EC50 | = | 361.0 | nM | 6.44 |
| CHEMBL1909434 | — | EC50 | = | 403.0 | nM | 6.39 |
| CHEMBL1672243 | — | EC50 | = | 426.0 | nM | 6.37 |
| CHEMBL1672238 | — | EC50 | = | 517.0 | nM | 6.29 |
| CHEMBL1672241 | — | EC50 | = | 556.0 | nM | 6.25 |
| CHEMBL1672232 | — | EC50 | = | 627.0 | nM | 6.20 |
| CHEMBL1672233 | — | EC50 | = | 845.0 | nM | 6.07 |
| CHEMBL1672242 | — | EC50 | = | 958.0 | nM | 6.02 |
| CHEMBL1385271 | — | EC50 | = | 977.0 | nM | 6.01 |
| CHEMBL1909435 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1672237 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1373422 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1672236 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL1672256 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1672257 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1509597 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1672240 | — | EC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL1672235 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1672239 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL1909431 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL1909433 | — | EC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL1672247 | — | EC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL1672246 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL1909436 | — | EC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL507522 | — | EC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL1672231 | — | EC50 | - | — | - | |
| CHEMBL1672230 | — | EC50 | - | — | - | |
| CHEMBL1909430 | — | EC50 | - | — | - | |
| CHEMBL1909432 | — | EC50 | - | — | - | |
| CHEMBL1909437 | — | EC50 | - | — | - | |
| CHEMBL1672255 | — | EC50 | - | — | - |