Assay Detail
Functional
CHEMBL1678503
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Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 A156T mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.11 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673210 | — | — | 1 | 8.32 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 6.42 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 5.97 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 5.14 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673210 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL501849 | SIMEPREVIR | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 1066.0 | nM | 5.97 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 7227.0 | nM | 5.14 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 20326.0 | nM | 4.69 |