Assay Detail
Binding
CHEMBL1678666
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Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Brucella suis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.53 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672445 | — | — | 1 | 8.14 |
| CHEMBL1090523 | — | — | 1 | 8.00 |
| CHEMBL6753 | — | — | 1 | 7.95 |
| CHEMBL1089967 | — | — | 1 | 7.84 |
| CHEMBL306195 | — | — | 1 | 7.22 |
| CHEMBL7146 | — | — | 1 | 7.17 |
| CHEMBL7092 | — | — | 1 | 7.10 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.08 |
| CHEMBL6853 | — | — | 1 | 7.08 |
| CHEMBL67755 | — | — | 1 | 7.08 |
| CHEMBL6685 | — | — | 1 | 7.08 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.06 |
| CHEMBL51668 | — | — | 1 | 7.05 |
| CHEMBL266026 | — | — | 1 | 7.03 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.00 |
| CHEMBL268439 | — | — | 1 | 6.97 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.95 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.93 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.89 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.89 |
| CHEMBL360356 | — | — | 1 | 6.78 |
| CHEMBL182455 | — | — | 1 | 6.71 |
| CHEMBL23350 | — | — | 1 | 6.67 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.52 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.39 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.38 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.21 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.20 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.19 |
| CHEMBL71611 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672445 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1090523 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL6753 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL1089967 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL306195 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL7146 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL7092 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL26 | SULPIRIDE | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL6853 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL67755 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL6685 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL51668 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL266026 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL268439 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL77517 | INDISULAM | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL118 | CELECOXIB | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL360356 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL182455 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL23350 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL865 | VALDECOXIB | Ki | = | 612.0 | nM | 6.21 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 625.0 | nM | 6.20 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL71611 | — | Ki | = | 663.0 | nM | 6.18 |
| CHEMBL414 | CARZENIDE | Ki | = | 697.0 | nM | 6.16 |
| CHEMBL266240 | — | Ki | = | 691.0 | nM | 6.16 |
| CHEMBL6919 | — | Ki | = | 758.0 | nM | 6.12 |
| CHEMBL6633 | — | Ki | = | 769.0 | nM | 6.11 |
| CHEMBL265674 | — | Ki | = | 847.0 | nM | 6.07 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL7204 | — | Ki | = | 4763.0 | nM | 5.32 |
| CHEMBL6705 | — | Ki | = | 5048.0 | nM | 5.30 |
| CHEMBL6784 | — | Ki | = | 5130.0 | nM | 5.29 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 5080.0 | nM | 5.29 |
| CHEMBL176495 | — | Ki | = | 5639.0 | nM | 5.25 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 5560.0 | nM | 5.25 |
| CHEMBL419 | MAFENIDE | Ki | = | 5910.0 | nM | 5.23 |
| CHEMBL7087 | — | Ki | = | 8560.0 | nM | 5.07 |