Assay Detail
Binding
CHEMBL1678667
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Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Brucella suis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.74 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089967 | — | — | 1 | 8.05 |
| CHEMBL1090523 | — | — | 1 | 8.04 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.77 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.75 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 7.72 |
| CHEMBL1672445 | — | — | 1 | 7.72 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.72 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.68 |
| CHEMBL6633 | — | — | 1 | 7.68 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.58 |
| CHEMBL51668 | — | — | 1 | 7.57 |
| CHEMBL360356 | — | — | 1 | 7.48 |
| CHEMBL6685 | — | — | 1 | 7.32 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.30 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.27 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.24 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.24 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL268439 | — | — | 1 | 7.16 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.12 |
| CHEMBL182455 | — | — | 1 | 7.12 |
| CHEMBL23350 | — | — | 1 | 7.10 |
| CHEMBL71611 | — | — | 1 | 6.73 |
| CHEMBL306195 | — | — | 1 | 6.61 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.47 |
| CHEMBL67755 | — | — | 1 | 6.46 |
| CHEMBL7146 | — | — | 1 | 6.13 |
| CHEMBL6919 | — | — | 1 | 6.12 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.12 |
| CHEMBL7092 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089967 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1090523 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL118 | CELECOXIB | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL865 | VALDECOXIB | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1672445 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL26 | SULPIRIDE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL6633 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL51668 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL360356 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL6685 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL77517 | INDISULAM | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL268439 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL182455 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL23350 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL71611 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL306195 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL414 | CARZENIDE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL67755 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL7146 | — | Ki | = | 745.0 | nM | 6.13 |
| CHEMBL6919 | — | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL419 | MAFENIDE | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL7092 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL6784 | — | Ki | = | 865.0 | nM | 6.06 |
| CHEMBL7087 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL266240 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL176495 | — | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL266026 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL6853 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL265674 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL6753 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL7204 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 4830.0 | nM | 5.32 |
| CHEMBL6705 | — | Ki | = | 5870.0 | nM | 5.23 |