Assay Detail
Functional
CHEMBL1679050
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Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.16 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672610 | — | — | 1 | 8.00 |
| CHEMBL1672609 | — | — | 1 | 7.96 |
| CHEMBL1672587 | — | — | 1 | 7.85 |
| CHEMBL1672592 | — | — | 1 | 7.70 |
| CHEMBL1672596 | — | — | 1 | 7.70 |
| CHEMBL1672602 | — | — | 1 | 7.47 |
| CHEMBL1672597 | — | — | 1 | 7.47 |
| CHEMBL1672599 | — | — | 1 | 7.46 |
| CHEMBL1672590 | — | — | 1 | 7.40 |
| CHEMBL584166 | — | — | 1 | 7.34 |
| CHEMBL1671868 | — | — | 1 | 7.25 |
| CHEMBL1672607 | — | — | 1 | 7.22 |
| CHEMBL1672588 | — | — | 1 | 7.11 |
| CHEMBL1672608 | — | — | 1 | 7.10 |
| CHEMBL1672601 | — | — | 1 | 7.05 |
| CHEMBL1672606 | — | — | 1 | 6.95 |
| CHEMBL1672591 | — | — | 1 | 6.89 |
| CHEMBL1672598 | — | — | 1 | 6.77 |
| CHEMBL1672589 | — | — | 1 | 6.74 |
| CHEMBL1672603 | — | — | 1 | 6.39 |
| CHEMBL1672600 | — | — | 1 | 6.30 |
| CHEMBL1672605 | — | — | 1 | 5.36 |
| CHEMBL1672604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672610 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1672609 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1672587 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1672592 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1672596 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1672602 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1672597 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1672599 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1672590 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL584166 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1671868 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1672607 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1672588 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1672608 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1672601 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1672606 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1672591 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1672598 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1672589 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL1672603 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1672600 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1672605 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1672604 | — | IC50 | > | 1000.0 | nM | - |