Assay Detail
Functional
CHEMBL1679579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.55 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671982 | — | — | 1 | 7.89 |
| CHEMBL1671969 | — | — | 1 | 7.80 |
| CHEMBL1671970 | — | — | 1 | 7.44 |
| CHEMBL1671971 | — | — | 1 | 7.40 |
| CHEMBL1671964 | — | — | 1 | 7.33 |
| CHEMBL1671974 | — | — | 1 | 7.24 |
| CHEMBL1671981 | — | — | 1 | 7.21 |
| CHEMBL1671972 | — | — | 1 | 7.17 |
| CHEMBL1671973 | — | — | 1 | 7.16 |
| CHEMBL1671966 | — | — | 1 | 7.10 |
| CHEMBL1671967 | — | — | 1 | 6.85 |
| CHEMBL1671965 | — | — | 1 | 6.78 |
| CHEMBL478524 | — | — | 1 | 6.72 |
| CHEMBL1671978 | — | — | 1 | 6.66 |
| CHEMBL1671963 | — | — | 1 | 6.62 |
| CHEMBL1671955 | — | — | 1 | 6.57 |
| CHEMBL1671959 | — | — | 1 | 6.55 |
| CHEMBL1671956 | — | — | 1 | 6.54 |
| CHEMBL1671986 | — | — | 1 | 6.46 |
| CHEMBL1671957 | — | — | 1 | 6.33 |
| CHEMBL1671975 | — | — | 1 | 6.33 |
| CHEMBL1671962 | — | — | 1 | 6.30 |
| CHEMBL1671869 | — | — | 1 | 6.27 |
| CHEMBL1671977 | — | — | 1 | 6.19 |
| CHEMBL1671968 | — | — | 1 | 6.14 |
| CHEMBL1671987 | — | — | 1 | 6.14 |
| CHEMBL1671984 | — | — | 1 | 6.14 |
| CHEMBL1671985 | — | — | 1 | 6.10 |
| CHEMBL1671976 | — | — | 1 | 6.05 |
| CHEMBL1671980 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671982 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1671969 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1671970 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1671971 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1671964 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1671974 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1671981 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1671972 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1671973 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1671966 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1671967 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1671965 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL478524 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1671978 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1671963 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1671955 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1671959 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1671956 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1671986 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1671975 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1671957 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1671962 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1671869 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1671977 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1671968 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1671987 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1671984 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1671985 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1671976 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1671980 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1671960 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1671958 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1671983 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1671979 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1671988 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1671961 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1671989 | — | IC50 | = | 2600.0 | nM | 5.58 |