Assay Detail
Functional
CHEMBL1679580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.67 | 7.05 |
| EC50 | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671982 | — | — | 1 | 7.05 |
| CHEMBL189753 | — | — | 1 | 6.43 |
| CHEMBL1671971 | — | — | 1 | 6.22 |
| CHEMBL1671972 | — | — | 1 | 6.16 |
| CHEMBL1671990 | — | — | 1 | 6.00 |
| CHEMBL1671969 | — | — | 1 | 5.82 |
| CHEMBL1671981 | — | — | 1 | 5.64 |
| CHEMBL1671965 | — | — | 1 | 5.64 |
| CHEMBL1671967 | — | — | 1 | 5.57 |
| CHEMBL1671966 | — | — | 1 | 5.47 |
| CHEMBL1671955 | — | — | 1 | 5.44 |
| CHEMBL1671963 | — | — | 1 | 5.35 |
| CHEMBL1671959 | — | — | 1 | 5.30 |
| CHEMBL1671964 | — | — | 1 | 5.23 |
| CHEMBL1671968 | — | — | 1 | 5.20 |
| CHEMBL1671978 | — | — | 1 | 5.16 |
| CHEMBL1671973 | — | — | 1 | 5.03 |
| CHEMBL1671970 | — | — | 1 | - |
| CHEMBL1671869 | — | — | 1 | - |
| CHEMBL1671958 | — | — | 1 | - |
| CHEMBL1671974 | — | — | 1 | - |
| CHEMBL1671975 | — | — | 1 | - |
| CHEMBL1671976 | — | — | 1 | - |
| CHEMBL1671957 | — | — | 1 | - |
| CHEMBL1671956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671982 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL189753 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1671971 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1671972 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1671990 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1671969 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1671981 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1671965 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1671967 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1671966 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1671955 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1671963 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1671959 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1671964 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1671968 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1671978 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1671973 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1671970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671975 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1671956 | — | IC50 | > | 10000.0 | nM | - |