Assay Detail
Functional
CHEMBL1679581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode voltage clamp technique
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit rho-2 (CHEMBL2375) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Cyclic Phosphinic Acids as GABAC ρ Receptor Antagonists: Design, Synthesis, and Pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.40 | 4.66 |
| Kb | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397209 | — | — | 2 | 4.66 |
| CHEMBL1672301 | — | — | 1 | 4.29 |
| CHEMBL1672299 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397209 | — | IC50 | = | 22090.0 | nM | 4.66 |
| CHEMBL1672301 | — | IC50 | = | 51310.0 | nM | 4.29 |
| CHEMBL1672299 | — | IC50 | = | 57130.0 | nM | 4.24 |
| CHEMBL397209 | — | Kb | = | 14900.0 | nM | - |