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Assay Detail

CHEMBL1679900

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human PPARdelta LBD by cell based luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Patch RJ, Searle LL, Kim AJ, De D, Zhu X, Askari HB, O'Neill JC, Abad MC, Rentzeperis D, Liu J, Kemmerer M, Lin L, Kasturi J, Geisler JG, Lenhard JM, Player MR, Gaul MD.
J Med Chem (2011) 54 : 788 -808
PubMed 21218783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 6.52 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38508 1 6.52
CHEMBL1671971 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38508 EC50 = 300.0 nM 6.52
CHEMBL1671971 EC50 > 15000.0 nM -