Assay Detail
Binding
CHEMBL1680102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]domperidone from human cloned dopamine D3 receptor expressed in mouse CCL1-3 cells by scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCL1-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.49 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.59 |
| CHEMBL1672303 | — | — | 1 | 6.37 |
| CHEMBL1672313 | — | — | 1 | 6.05 |
| CHEMBL27559 | — | — | 1 | 5.77 |
| CHEMBL1672304 | — | — | 1 | 5.66 |
| CHEMBL106622 | — | — | 1 | - |
| CHEMBL405345 | — | — | 1 | - |
| CHEMBL1672302 | — | — | 1 | - |
| CHEMBL1672305 | — | — | 1 | - |
| CHEMBL1672306 | — | — | 1 | - |
| CHEMBL1672307 | — | — | 1 | - |
| CHEMBL1672308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1672303 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL1672313 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL27559 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1672304 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL106622 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL405345 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1672302 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1672305 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1672306 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1672307 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1672308 | — | Ki | > | 10000.0 | nM | - |