Assay Detail
Binding
CHEMBL1680106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]domperidone from human cloned dopamine D3 receptor high binding site expressed in mouse CCL1-3 cells by scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCL1-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.88 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672303 | — | — | 1 | 8.96 |
| CHEMBL27559 | — | — | 1 | 8.92 |
| CHEMBL1672304 | — | — | 1 | 8.72 |
| CHEMBL106622 | — | — | 1 | 8.42 |
| CHEMBL405345 | — | — | 1 | 6.89 |
| CHEMBL1672305 | — | — | 1 | 6.64 |
| CHEMBL1672306 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672303 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL27559 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1672304 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL106622 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL405345 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1672305 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1672306 | — | Ki | = | 250.0 | nM | 6.60 |