Assay Detail
Binding
CHEMBL1680140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.60 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | — | 1 | 6.30 |
| CHEMBL1672332 | BUTYRYLHYDROXAMIC ACID | — | 1 | 5.70 |
| CHEMBL186311 | VALPROPYLHYDROXAMIC ACID | — | 1 | 4.80 |
| CHEMBL14227 | BUTYRIC ACID | 2.0 | 1 | - |
| CHEMBL1469 | PHENYLBUTANOIC ACID | 4.0 | 1 | - |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1672332 | BUTYRYLHYDROXAMIC ACID | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL186311 | VALPROPYLHYDROXAMIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL14227 | BUTYRIC ACID | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1469 | PHENYLBUTANOIC ACID | IC50 | = | 240000.0 | nM | - |
| CHEMBL109 | VALPROIC ACID | IC50 | > | 2000000.0 | nM | - |