Assay Detail
Binding
CHEMBL1680281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.75 | 8.30 |
| Ki | 1 | 8.43 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672354 | — | — | 2 | 8.43 |
| CHEMBL1672353 | — | — | 1 | 8.30 |
| CHEMBL1671874 | — | — | 1 | 7.96 |
| CHEMBL1093184 | — | — | 1 | 7.80 |
| CHEMBL1672352 | — | — | 1 | 7.77 |
| CHEMBL1672351 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672354 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1672353 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1671874 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1093184 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1672352 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1672354 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1672351 | — | IC50 | = | 82.0 | nM | 7.09 |