Assay Detail
Binding
CHEMBL1680619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]methyltrienolone from human mineralocorticoid receptor expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.98 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235206 | — | — | 1 | 9.50 |
| CHEMBL1672542 | — | — | 1 | 9.19 |
| CHEMBL391231 | — | — | 1 | 8.82 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | — | 1 | 7.06 |
| CHEMBL1672541 | — | — | 1 | 6.90 |
| CHEMBL1672547 | — | — | 1 | 6.07 |
| CHEMBL1672548 | — | — | 1 | 6.00 |
| CHEMBL1672546 | — | — | 1 | 5.86 |
| CHEMBL1672549 | — | — | 1 | 5.84 |
| CHEMBL1672545 | — | — | 1 | 5.83 |
| CHEMBL1672544 | — | — | 1 | 5.75 |
| CHEMBL1672543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235206 | — | Ki | = | 0.319 | nM | 9.50 |
| CHEMBL1672542 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL391231 | — | Ki | = | 1.51 | nM | 8.82 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | Ki | = | 86.8 | nM | 7.06 |
| CHEMBL1672541 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL1672547 | — | Ki | = | 849.0 | nM | 6.07 |
| CHEMBL1672548 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1672546 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL1672549 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL1672545 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL1672544 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL1672543 | — | Ki | > | 4170.0 | nM | - |