Assay Detail
Functional
CHEMBL1680624
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human mineralocorticoid receptor expressed in HEK293 cells assessed as inhibition of R5050-induced transcriptional activity by GRE-driven luciferase reporter gene assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.17 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235206 | — | — | 1 | 7.57 |
| CHEMBL1672542 | — | — | 1 | 7.19 |
| CHEMBL391231 | — | — | 1 | 6.51 |
| CHEMBL1672546 | — | — | 1 | 5.62 |
| CHEMBL1672547 | — | — | 1 | 5.09 |
| CHEMBL1672548 | — | — | 1 | 5.01 |
| CHEMBL1672549 | — | — | 1 | - |
| CHEMBL1672541 | — | — | 1 | - |
| CHEMBL1672545 | — | — | 1 | - |
| CHEMBL1672544 | — | — | 1 | - |
| CHEMBL1672543 | — | — | 1 | - |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235206 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL1672542 | — | IC50 | = | 64.1 | nM | 7.19 |
| CHEMBL391231 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL1672546 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL1672547 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL1672548 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1672549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1672541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1672545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1672544 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1672543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | IC50 | > | 10000.0 | nM | - |