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Assay Detail

CHEMBL1680823

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PSB0413 from human platelet P2Y12 receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 12 (CHEMBL2001)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.
Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE.
J Med Chem (2011) 54 : 817 -830
PubMed 21207957 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.34 6.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL509572 1 6.18
CHEMBL223344 RB 2 1 6.17
CHEMBL496401 1 5.72
CHEMBL499580 1 5.42
CHEMBL271672 1 5.17
CHEMBL256057 ACID BLUE 25 1 5.01
CHEMBL445413 1 5.00
CHEMBL496030 1 5.00
CHEMBL1671995 1 5.00
CHEMBL1672104 1 4.77
CHEMBL1672100 1 -
CHEMBL1672101 1 -
CHEMBL1672105 1 -
CHEMBL1672106 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL509572 Ki = 660.0 nM 6.18
CHEMBL223344 RB 2 Ki = 680.0 nM 6.17
CHEMBL496401 Ki = 1900.0 nM 5.72
CHEMBL499580 Ki = 3760.0 nM 5.42
CHEMBL271672 Ki = 6760.0 nM 5.17
CHEMBL256057 ACID BLUE 25 Ki = 9830.0 nM 5.01
CHEMBL445413 Ki = 10000.0 nM 5.00
CHEMBL496030 Ki = 10000.0 nM 5.00
CHEMBL1671995 Ki = 10000.0 nM 5.00
CHEMBL1672104 Ki = 17100.0 nM 4.77
CHEMBL1672100 Ki - -
CHEMBL1672101 Ki - -
CHEMBL1672105 Ki - -
CHEMBL1672106 Ki - -