Assay Detail
Binding
CHEMBL1680920
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Inhibition of human soluble epoxide hydrolase in cell free system
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.51 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672132 | — | — | 1 | 8.64 |
| CHEMBL1672128 | — | — | 1 | 8.19 |
| CHEMBL1615216 | — | — | 2 | 8.07 |
| CHEMBL1672131 | — | — | 1 | 7.52 |
| CHEMBL1672130 | — | — | 1 | 7.40 |
| CHEMBL1672129 | — | — | 1 | 7.21 |
| CHEMBL1615212 | — | — | 2 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672132 | — | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL1672128 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL1615216 | — | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL1615216 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1672131 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL1672130 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1672129 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL1615212 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL1615212 | — | IC50 | = | 562.34 | nM | 6.25 |