Assay Detail
Binding
CHEMBL1680922
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Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.86 | 8.33 |
| pIC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672128 | — | — | 1 | 8.33 |
| CHEMBL1672132 | — | — | 1 | 8.10 |
| CHEMBL1615216 | — | — | 2 | 7.89 |
| CHEMBL1672130 | — | — | 1 | 7.09 |
| CHEMBL1672129 | — | — | 1 | - |
| CHEMBL1672131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672128 | — | IC50 | = | 4.677 | nM | 8.33 |
| CHEMBL1672132 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1615216 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1615216 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL1672130 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL1672129 | — | pIC50 | - | — | - | |
| CHEMBL1672131 | — | pIC50 | - | — | - |