Assay Detail
Binding
CHEMBL1681028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of trimethoprim-resistant Staphylococcus aureus Type S1 dihydrofolate reductase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro and in vivo properties of dihydrophthalazine antifolates, a novel family of antibacterial drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.35 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673175 | — | — | 1 | 7.46 |
| CHEMBL1673173 | — | — | 1 | 7.01 |
| CHEMBL1673177 | — | — | 1 | 7.01 |
| CHEMBL1650306 | — | — | 1 | 6.92 |
| CHEMBL1650308 | — | — | 1 | 6.81 |
| CHEMBL1673176 | — | — | 1 | 6.00 |
| CHEMBL1673174 | — | — | 1 | 5.88 |
| CHEMBL1673178 | — | — | 1 | 5.59 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.48 |
| CHEMBL1650307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673175 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL1673173 | — | IC50 | = | 98.3 | nM | 7.01 |
| CHEMBL1673177 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1650306 | — | IC50 | = | 121.1 | nM | 6.92 |
| CHEMBL1650308 | — | IC50 | = | 153.6 | nM | 6.81 |
| CHEMBL1673176 | — | IC50 | = | 1009.0 | nM | 6.00 |
| CHEMBL1673174 | — | IC50 | = | 1327.0 | nM | 5.88 |
| CHEMBL1673178 | — | IC50 | = | 2586.0 | nM | 5.59 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 32997.0 | nM | 4.48 |
| CHEMBL1650307 | — | IC50 | - | — | - |