Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1685124

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]ditolylguanidine from sigma2 receptor in guinea pig brain membrane
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Brain
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors.
Fan KH, Lever JR, Lever SZ.
Bioorg Med Chem (2011) 19 : 1852 -1859
PubMed 21376604 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 6.52 9.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1682080 1 9.09
CHEMBL291439 1 8.57
CHEMBL54 HALOPERIDOL 4.0 1 8.02
CHEMBL408867 [11C]SA4503 1 7.05
CHEMBL1682083 1 6.50
CHEMBL1682081 1 6.13
CHEMBL1682086 1 5.67
CHEMBL391153 1 5.34
CHEMBL1682085 1 5.24
CHEMBL1682084 1 5.05
CHEMBL1682082 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1682080 Ki = 0.82 nM 9.09
CHEMBL291439 Ki = 2.7 nM 8.57
CHEMBL54 HALOPERIDOL Ki = 9.58 nM 8.02
CHEMBL408867 [11C]SA4503 Ki = 89.51 nM 7.05
CHEMBL1682083 Ki = 315.0 nM 6.50
CHEMBL1682081 Ki = 734.0 nM 6.13
CHEMBL1682086 Ki = 2126.0 nM 5.67
CHEMBL391153 Ki = 4616.0 nM 5.34
CHEMBL1682085 Ki = 5823.0 nM 5.24
CHEMBL1682084 Ki = 8957.0 nM 5.05
CHEMBL1682082 Ki = 9681.0 nM 5.01