Assay Detail
Binding
CHEMBL1685181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GSK3-beta expressed in baculovirus infected SF9 cells after 60 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.36 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682851 | — | — | 1 | 8.21 |
| CHEMBL1682850 | — | — | 1 | 8.07 |
| CHEMBL1682842 | — | — | 1 | 7.76 |
| CHEMBL501724 | — | — | 1 | 7.76 |
| CHEMBL1682838 | — | — | 1 | 7.30 |
| CHEMBL1682849 | — | — | 1 | 7.29 |
| CHEMBL1682839 | — | — | 1 | 7.21 |
| CHEMBL1682852 | — | — | 1 | 7.20 |
| CHEMBL1682848 | — | — | 1 | 7.08 |
| CHEMBL1682853 | — | — | 1 | 6.94 |
| CHEMBL1682847 | — | — | 1 | 6.88 |
| CHEMBL1682840 | — | — | 1 | 6.63 |
| CHEMBL1682845 | — | — | 1 | - |
| CHEMBL1682846 | — | — | 1 | - |
| CHEMBL1682844 | — | — | 1 | - |
| CHEMBL1682843 | — | — | 1 | - |
| CHEMBL1682841 | — | — | 1 | - |
| CHEMBL1682837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682851 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1682850 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1682842 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL501724 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL1682838 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL1682849 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1682839 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1682852 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL1682848 | — | IC50 | = | 84.1 | nM | 7.08 |
| CHEMBL1682853 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1682847 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL1682840 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1682845 | — | IC50 | > | 252.0 | nM | - |
| CHEMBL1682846 | — | IC50 | > | 260.0 | nM | - |
| CHEMBL1682844 | — | IC50 | > | 731.0 | nM | - |
| CHEMBL1682843 | — | IC50 | > | 401.0 | nM | - |
| CHEMBL1682841 | — | IC50 | > | 592.0 | nM | - |
| CHEMBL1682837 | — | IC50 | > | 894.0 | nM | - |