Assay Detail
Binding
CHEMBL1685196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CEM-CCRF |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.48 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682996 | — | — | 1 | 7.96 |
| CHEMBL1682997 | — | — | 1 | 7.78 |
| CHEMBL1682998 | — | — | 1 | 7.45 |
| CHEMBL1682995 | — | — | 1 | 7.20 |
| CHEMBL1682994 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682996 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1682997 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL1682998 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL1682995 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL1682994 | — | IC50 | = | 96.1 | nM | 7.02 |