Assay Detail
Binding
CHEMBL1685279
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Inhibition of Nitric oxide synthase activity in mouse BV2 cells assessed as LPS-induced NO production after 24 hrs by Griess reaction
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.49 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682094 | — | — | 1 | 6.52 |
| CHEMBL1682087 | — | — | 1 | 6.30 |
| CHEMBL1682090 | — | — | 1 | 5.92 |
| CHEMBL1682095 | — | — | 1 | 5.85 |
| CHEMBL1682105 | — | — | 1 | 5.80 |
| CHEMBL1681792 | — | — | 1 | 5.77 |
| CHEMBL1682106 | — | — | 1 | 5.77 |
| CHEMBL1682093 | — | — | 1 | 5.72 |
| CHEMBL1682107 | — | — | 1 | 5.72 |
| CHEMBL1682102 | — | — | 1 | 5.68 |
| CHEMBL1682088 | — | — | 1 | 5.68 |
| CHEMBL1682091 | — | — | 1 | 5.62 |
| CHEMBL1682100 | — | — | 1 | 5.57 |
| CHEMBL1682089 | — | — | 1 | 5.55 |
| CHEMBL1682101 | — | — | 1 | 5.51 |
| CHEMBL1682108 | — | — | 1 | 5.46 |
| CHEMBL1682103 | — | — | 1 | 5.46 |
| CHEMBL1682096 | — | — | 1 | 5.18 |
| CHEMBL1682092 | — | — | 1 | 5.12 |
| CHEMBL1682104 | — | — | 1 | 4.96 |
| CHEMBL1682097 | — | — | 1 | 4.80 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.72 |
| CHEMBL1682099 | — | — | 1 | 4.59 |
| CHEMBL1682098 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682094 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1682087 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1682090 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1682095 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1682105 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1681792 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1682106 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1682093 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1682107 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1682102 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1682088 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1682091 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1682100 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1682089 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1682101 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1682108 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1682103 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1682096 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1682092 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1682104 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1682097 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL7890 | L-NAME | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL1682099 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL1682098 | — | IC50 | = | 30500.0 | nM | 4.52 |