Assay Detail
Binding
CHEMBL1685403
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Inhibition of GSK3-beta after 1 hr
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.53 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682355 | — | — | 1 | 7.80 |
| CHEMBL1682348 | — | — | 1 | 7.64 |
| CHEMBL1682351 | — | — | 1 | 7.58 |
| CHEMBL1682356 | — | — | 1 | 7.55 |
| CHEMBL1682345 | — | — | 1 | 7.41 |
| CHEMBL1682347 | — | — | 1 | 7.35 |
| CHEMBL1682354 | — | — | 1 | 7.32 |
| CHEMBL1682353 | — | — | 1 | 7.16 |
| CHEMBL1682352 | — | — | 1 | 7.16 |
| CHEMBL1682350 | — | — | 1 | 7.04 |
| CHEMBL1682349 | — | — | 1 | 6.71 |
| CHEMBL1682346 | — | — | 1 | 6.58 |
| CHEMBL1682344 | — | — | 1 | 6.35 |
| CHEMBL1682342 | — | — | 1 | 6.35 |
| CHEMBL1682358 | — | — | 1 | 6.35 |
| CHEMBL1682343 | — | — | 1 | 6.28 |
| CHEMBL1682341 | — | — | 1 | 6.27 |
| CHEMBL1682357 | — | — | 1 | 6.24 |
| CHEMBL1682340 | — | — | 1 | 6.05 |
| CHEMBL1682339 | — | — | 1 | 5.89 |
| CHEMBL1682335 | — | — | 1 | 5.69 |
| CHEMBL1682359 | — | — | 1 | 5.60 |
| CHEMBL1682338 | — | — | 1 | 5.46 |
| CHEMBL1682360 | — | — | 1 | 5.42 |
| CHEMBL1681795 | — | — | 1 | 5.37 |
| CHEMBL1682337 | — | — | 1 | 5.28 |
| CHEMBL1682336 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682355 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1682348 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1682351 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1682356 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1682345 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1682347 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL1682354 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1682353 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1682352 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1682350 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL1682349 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL1682346 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL1682344 | — | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL1682342 | — | Ki | = | 446.0 | nM | 6.35 |
| CHEMBL1682358 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL1682343 | — | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL1682341 | — | Ki | = | 542.0 | nM | 6.27 |
| CHEMBL1682357 | — | Ki | = | 572.0 | nM | 6.24 |
| CHEMBL1682340 | — | Ki | = | 891.0 | nM | 6.05 |
| CHEMBL1682339 | — | Ki | = | 1298.0 | nM | 5.89 |
| CHEMBL1682335 | — | Ki | = | 2026.0 | nM | 5.69 |
| CHEMBL1682359 | — | Ki | = | 2530.0 | nM | 5.60 |
| CHEMBL1682338 | — | Ki | = | 3466.0 | nM | 5.46 |
| CHEMBL1682360 | — | Ki | = | 3810.0 | nM | 5.42 |
| CHEMBL1681795 | — | Ki | = | 4272.0 | nM | 5.37 |
| CHEMBL1682337 | — | Ki | = | 5216.0 | nM | 5.28 |
| CHEMBL1682336 | — | Ki | > | 5450.0 | nM | - |