Assay Detail
Binding
CHEMBL1685404
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Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.30 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682358 | — | — | 1 | 7.80 |
| CHEMBL1682346 | — | — | 1 | 7.04 |
| CHEMBL1682340 | — | — | 1 | 6.55 |
| CHEMBL1682345 | — | — | 1 | 6.55 |
| CHEMBL1682357 | — | — | 1 | 6.46 |
| CHEMBL1682359 | — | — | 1 | 6.32 |
| CHEMBL1682343 | — | — | 1 | 6.19 |
| CHEMBL1682335 | — | — | 1 | 6.12 |
| CHEMBL1682339 | — | — | 1 | 6.10 |
| CHEMBL1682342 | — | — | 1 | 6.05 |
| CHEMBL1682341 | — | — | 1 | 5.89 |
| CHEMBL1682338 | — | — | 1 | 5.84 |
| CHEMBL1682337 | — | — | 1 | 5.84 |
| CHEMBL1682348 | — | — | 1 | 5.84 |
| CHEMBL1682344 | — | — | 1 | 5.84 |
| CHEMBL1681795 | — | — | 1 | - |
| CHEMBL1682360 | — | — | 1 | - |
| CHEMBL1682356 | — | — | 1 | - |
| CHEMBL1682355 | — | — | 1 | - |
| CHEMBL1682354 | — | — | 1 | - |
| CHEMBL1682353 | — | — | 1 | - |
| CHEMBL1682352 | — | — | 1 | - |
| CHEMBL1682351 | — | — | 1 | - |
| CHEMBL1682350 | — | — | 1 | - |
| CHEMBL1682349 | — | — | 1 | - |
| CHEMBL1682347 | — | — | 1 | - |
| CHEMBL1682336 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682358 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1682346 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL1682340 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL1682345 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL1682357 | — | Ki | = | 351.0 | nM | 6.46 |
| CHEMBL1682359 | — | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL1682343 | — | Ki | = | 644.0 | nM | 6.19 |
| CHEMBL1682335 | — | Ki | = | 756.0 | nM | 6.12 |
| CHEMBL1682339 | — | Ki | = | 791.0 | nM | 6.10 |
| CHEMBL1682342 | — | Ki | = | 898.0 | nM | 6.05 |
| CHEMBL1682341 | — | Ki | = | 1282.0 | nM | 5.89 |
| CHEMBL1682338 | — | Ki | = | 1453.0 | nM | 5.84 |
| CHEMBL1682337 | — | Ki | = | 1453.0 | nM | 5.84 |
| CHEMBL1682348 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL1682344 | — | Ki | = | 1453.0 | nM | 5.84 |
| CHEMBL1681795 | — | Ki | - | — | - | |
| CHEMBL1682360 | — | Ki | > | 1453.0 | nM | - |
| CHEMBL1682356 | — | Ki | - | — | - | |
| CHEMBL1682355 | — | Ki | - | — | - | |
| CHEMBL1682354 | — | Ki | - | — | - | |
| CHEMBL1682353 | — | Ki | - | — | - | |
| CHEMBL1682352 | — | Ki | - | — | - | |
| CHEMBL1682351 | — | Ki | - | — | - | |
| CHEMBL1682350 | — | Ki | - | — | - | |
| CHEMBL1682349 | — | Ki | - | — | - | |
| CHEMBL1682347 | — | Ki | > | 1453.0 | nM | - |
| CHEMBL1682336 | — | Ki | > | 1450.0 | nM | - |