Assay Detail
Binding
CHEMBL1685407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.06 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682345 | — | — | 1 | 6.04 |
| CHEMBL1682344 | — | — | 1 | 5.65 |
| CHEMBL1681795 | — | — | 1 | 5.43 |
| CHEMBL1682347 | — | — | 1 | 5.38 |
| CHEMBL1682358 | — | — | 1 | 5.29 |
| CHEMBL1682335 | — | — | 1 | 5.08 |
| CHEMBL1682350 | — | — | 1 | 4.99 |
| CHEMBL1682351 | — | — | 1 | 4.92 |
| CHEMBL1682354 | — | — | 1 | 4.69 |
| CHEMBL1682355 | — | — | 1 | 4.44 |
| CHEMBL1682349 | — | — | 1 | 4.42 |
| CHEMBL1682356 | — | — | 1 | 4.38 |
| CHEMBL1682336 | — | — | 1 | - |
| CHEMBL1682337 | — | — | 1 | - |
| CHEMBL1682338 | — | — | 1 | - |
| CHEMBL1682339 | — | — | 1 | - |
| CHEMBL1682340 | — | — | 1 | - |
| CHEMBL1682341 | — | — | 1 | - |
| CHEMBL1682342 | — | — | 1 | - |
| CHEMBL1682343 | — | — | 1 | - |
| CHEMBL1682346 | — | — | 1 | - |
| CHEMBL1682352 | — | — | 1 | - |
| CHEMBL1682360 | — | — | 1 | - |
| CHEMBL1682359 | — | — | 1 | - |
| CHEMBL1682357 | — | — | 1 | - |
| CHEMBL1682353 | — | — | 1 | - |
| CHEMBL1682348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682345 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL1682344 | — | Ki | = | 2219.0 | nM | 5.65 |
| CHEMBL1681795 | — | Ki | = | 3685.0 | nM | 5.43 |
| CHEMBL1682347 | — | Ki | = | 4153.0 | nM | 5.38 |
| CHEMBL1682358 | — | Ki | = | 5155.0 | nM | 5.29 |
| CHEMBL1682335 | — | Ki | = | 8359.0 | nM | 5.08 |
| CHEMBL1682350 | — | Ki | = | 10153.0 | nM | 4.99 |
| CHEMBL1682351 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1682354 | — | Ki | = | 20307.0 | nM | 4.69 |
| CHEMBL1682355 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL1682349 | — | Ki | = | 37846.0 | nM | 4.42 |
| CHEMBL1682356 | — | Ki | = | 41538.0 | nM | 4.38 |
| CHEMBL1682336 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682337 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682338 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682339 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682340 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682341 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682342 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682343 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682346 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682352 | — | Ki | = | 165230.0 | nM | - |
| CHEMBL1682360 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682359 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682357 | — | Ki | > | 8570.0 | nM | - |
| CHEMBL1682353 | — | Ki | - | — | - | |
| CHEMBL1682348 | — | Ki | - | — | - |