Assay Detail
Binding
CHEMBL1685408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.04 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682354 | — | — | 1 | 7.82 |
| CHEMBL1682358 | — | — | 1 | 7.80 |
| CHEMBL1682355 | — | — | 1 | 7.75 |
| CHEMBL1682341 | — | — | 1 | 7.75 |
| CHEMBL1682342 | — | — | 1 | 7.72 |
| CHEMBL1682357 | — | — | 1 | 7.55 |
| CHEMBL1682348 | — | — | 1 | 7.41 |
| CHEMBL1682356 | — | — | 1 | 7.39 |
| CHEMBL1682339 | — | — | 1 | 7.36 |
| CHEMBL1682343 | — | — | 1 | 7.21 |
| CHEMBL1682346 | — | — | 1 | 7.19 |
| CHEMBL1682349 | — | — | 1 | 7.17 |
| CHEMBL1682345 | — | — | 1 | 7.01 |
| CHEMBL1682347 | — | — | 1 | 7.01 |
| CHEMBL1682340 | — | — | 1 | 7.00 |
| CHEMBL1682335 | — | — | 1 | 6.97 |
| CHEMBL1682359 | — | — | 1 | 6.95 |
| CHEMBL1682351 | — | — | 1 | 6.75 |
| CHEMBL1682344 | — | — | 1 | 6.68 |
| CHEMBL1682337 | — | — | 1 | 6.64 |
| CHEMBL1682350 | — | — | 1 | 6.54 |
| CHEMBL1682352 | — | — | 1 | 6.54 |
| CHEMBL1682360 | — | — | 1 | 6.50 |
| CHEMBL1682338 | — | — | 1 | 6.45 |
| CHEMBL1682353 | — | — | 1 | 6.43 |
| CHEMBL1681795 | — | — | 1 | 6.40 |
| CHEMBL1682336 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682354 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1682358 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1682355 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1682341 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1682342 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1682357 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1682348 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1682356 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1682339 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1682343 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1682346 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1682349 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL1682345 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL1682347 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL1682340 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1682335 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL1682359 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL1682351 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1682344 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL1682337 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1682350 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1682352 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1682360 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL1682338 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL1682353 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL1681795 | — | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL1682336 | — | Ki | = | 635.0 | nM | 6.20 |