Assay Detail
Binding
CHEMBL1685467
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Inhibition of MEK after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.53 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1614766 | RO-4987655 | 1.0 | 1 | 8.28 |
| CHEMBL1684493 | — | — | 1 | 8.14 |
| CHEMBL1684492 | — | — | 1 | 8.07 |
| CHEMBL464238 | — | — | 1 | 7.85 |
| CHEMBL1684490 | — | — | 1 | 7.82 |
| CHEMBL1684491 | — | — | 1 | 7.72 |
| CHEMBL1684487 | — | — | 1 | 7.43 |
| CHEMBL1684496 | — | — | 1 | 7.38 |
| CHEMBL1684489 | — | — | 1 | 7.32 |
| CHEMBL1684488 | — | — | 1 | 7.17 |
| CHEMBL1684494 | — | — | 1 | 7.07 |
| CHEMBL464239 | — | — | 1 | 7.00 |
| CHEMBL1684486 | — | — | 1 | 6.63 |
| CHEMBL1684495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1614766 | RO-4987655 | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1684493 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1684492 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL464238 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1684490 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1684491 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1684487 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1684496 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1684489 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1684488 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1684494 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL464239 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1684486 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL1684495 | — | IC50 | > | 250.0 | nM | - |