Assay Detail

CHEMBL1685479

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Functional

Cytotoxicity against human MIAPaCa2 cells expressing Kras G12C mutant after 4 days

ChEMBL ↗

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Target

MIA PaCa-2 (CHEMBL614725) ↗

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MIA PaCa-2 (CHEMBL614725) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MIA PaCa-2

CHEMBL614725

Anchored from Assay target.

Protein identity MIA PaCa-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MIA PaCa-2
Confidence	1 — Organism
Curated By	Autocuration

Target

MIA PaCa-2 (CHEMBL614725) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schück V, Shimma N.
Bioorg Med Chem Lett (2011) 21 : 1795 -1801
PubMed 21316218 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.48	8.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1614766	RO-4987655	1.0	1	8.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1614766	RO-4987655	IC50	=	3.3	nM	8.48