Assay Detail
Binding
CHEMBL1685943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IMPDH2 by Spectrophotometer
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.87 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 8.15 |
| CHEMBL1683637 | — | — | 1 | 7.85 |
| CHEMBL1683640 | — | — | 1 | 7.62 |
| CHEMBL1683638 | — | — | 1 | 7.52 |
| CHEMBL1683755 | — | — | 1 | 7.47 |
| CHEMBL1683743 | — | — | 1 | 7.43 |
| CHEMBL1683639 | — | — | 1 | 7.42 |
| CHEMBL1683752 | — | — | 1 | 7.41 |
| CHEMBL1683754 | — | — | 1 | 7.36 |
| CHEMBL1683742 | — | — | 1 | 7.22 |
| CHEMBL1683745 | — | — | 1 | 7.14 |
| CHEMBL1683744 | — | — | 1 | 7.08 |
| CHEMBL1683749 | — | — | 1 | 7.08 |
| CHEMBL2364562 | — | — | 1 | 6.96 |
| CHEMBL1683748 | — | — | 1 | 6.78 |
| CHEMBL410744 | — | — | 1 | 6.60 |
| CHEMBL1683747 | — | — | 1 | 6.11 |
| CHEMBL1683753 | — | — | 1 | 5.72 |
| CHEMBL1683746 | MYCOPHENOLIC ETHYLENEBIS | — | 1 | 5.42 |
| CHEMBL1683751 | — | — | 1 | 5.18 |
| CHEMBL1683750 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1683637 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1683640 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1683638 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1683755 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1683743 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1683639 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1683752 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1683754 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1683742 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1683745 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL1683744 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL1683749 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL2364562 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1683748 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL410744 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1683747 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL1683753 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL1683746 | MYCOPHENOLIC ETHYLENEBIS | Ki | = | 3770.0 | nM | 5.42 |
| CHEMBL1683751 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL1683750 | — | Ki | = | 18800.0 | nM | 4.73 |