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Assay Detail

CHEMBL1685944

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.
Felczak K, Chen L, Wilson D, Williams J, Vince R, Petrelli R, Jayaram HN, Kusumanchi P, Kumar M, Pankiewicz KW.
Bioorg Med Chem (2011) 19 : 1594 -1605
PubMed 21324702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.32 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1683640 1 6.35
CHEMBL1683639 1 6.00
CHEMBL1683745 1 5.40
CHEMBL1683638 1 5.33
CHEMBL410744 1 5.24
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 5.11
CHEMBL1683744 1 4.98
CHEMBL1683743 1 4.15
CHEMBL1683637 1 -
CHEMBL1683742 1 -
CHEMBL1683746 MYCOPHENOLIC ETHYLENEBIS 1 -
CHEMBL1683747 1 -
CHEMBL1683748 1 -
CHEMBL1683749 1 -
CHEMBL1683750 1 -
CHEMBL1683751 1 -
CHEMBL1683752 1 -
CHEMBL1683753 1 -
CHEMBL1683754 1 -
CHEMBL1683755 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1683640 IC50 = 450.0 nM 6.35
CHEMBL1683639 IC50 = 1000.0 nM 6.00
CHEMBL1683745 IC50 = 4000.0 nM 5.40
CHEMBL1683638 IC50 = 4700.0 nM 5.33
CHEMBL410744 IC50 = 5700.0 nM 5.24
CHEMBL866 MYCOPHENOLIC ACID IC50 = 7700.0 nM 5.11
CHEMBL1683744 IC50 = 10500.0 nM 4.98
CHEMBL1683743 IC50 = 71300.0 nM 4.15
CHEMBL1683637 IC50 - -
CHEMBL1683742 IC50 = 118400.0 nM -
CHEMBL1683746 MYCOPHENOLIC ETHYLENEBIS IC50 > 100000.0 nM -
CHEMBL1683747 IC50 > 100000.0 nM -
CHEMBL1683748 IC50 > 100000.0 nM -
CHEMBL1683749 IC50 > 100000.0 nM -
CHEMBL1683750 IC50 > 100000.0 nM -
CHEMBL1683751 IC50 > 100000.0 nM -
CHEMBL1683752 IC50 > 100000.0 nM -
CHEMBL1683753 IC50 > 100000.0 nM -
CHEMBL1683754 IC50 > 100000.0 nM -
CHEMBL1683755 IC50 > 100000.0 nM -