Assay Detail
Functional
CHEMBL1686136
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA by Southern blotting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiviral agents 3. Discovery of a novel small molecule non-nucleoside inhibitor of hepatitis B virus (HBV).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.10 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223980 | — | — | 1 | 8.05 |
| CHEMBL1223983 | — | — | 1 | 7.30 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.22 |
| CHEMBL1223979 | — | — | 1 | 7.02 |
| CHEMBL1223977 | — | — | 1 | 6.81 |
| CHEMBL1223984 | — | — | 1 | 6.40 |
| CHEMBL1683947 | — | — | 1 | 6.18 |
| CHEMBL1223975 | — | — | 1 | 5.82 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 5.47 |
| CHEMBL1683840 | — | — | 1 | 5.41 |
| CHEMBL1683948 | — | — | 1 | 5.37 |
| CHEMBL1223978 | — | — | 1 | 5.10 |
| CHEMBL1223974 | — | — | 1 | 5.00 |
| CHEMBL1683946 | — | — | 1 | 4.25 |
| CHEMBL1223982 | — | — | 1 | - |
| CHEMBL1224083 | — | — | 1 | - |
| CHEMBL1683839 | — | — | 1 | - |
| CHEMBL509065 | CONOCURVONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223980 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1223983 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1223979 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1223977 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1223984 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1683947 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1223975 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1683840 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1683948 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1223978 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1223974 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1683946 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1223982 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1224083 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1683839 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL509065 | CONOCURVONE | EC50 | > | 10000.0 | nM | - |