Assay Detail
Binding
CHEMBL1686233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aggrecanase-mediated aggrecan degradation in IL-1-stimulated bovine nasal cartilage explant after 48 hrs by immunoblot method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Nasal cartilage |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.51 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615187 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615187 | — | IC50 | = | 310.0 | nM | 6.51 |