Assay Detail
Binding
CHEMBL1686236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.66 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL1683472 | — | — | 1 | 7.10 |
| CHEMBL1683475 | — | — | 1 | 6.40 |
| CHEMBL1683470 | — | — | 1 | 6.02 |
| CHEMBL1683467 | — | — | 1 | 5.93 |
| CHEMBL1683466 | — | — | 1 | 5.92 |
| CHEMBL1683468 | — | — | 1 | 5.81 |
| CHEMBL1683474 | — | — | 1 | 5.75 |
| CHEMBL1683471 | — | — | 1 | 5.65 |
| CHEMBL1683473 | — | — | 1 | 5.64 |
| CHEMBL1683469 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1683472 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL1683475 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL1683470 | — | Ki | = | 963.0 | nM | 6.02 |
| CHEMBL1683467 | — | Ki | = | 1165.0 | nM | 5.93 |
| CHEMBL1683466 | — | Ki | = | 1207.0 | nM | 5.92 |
| CHEMBL1683468 | — | Ki | = | 1563.0 | nM | 5.81 |
| CHEMBL1683474 | — | Ki | = | 1773.0 | nM | 5.75 |
| CHEMBL1683471 | — | Ki | = | 2254.0 | nM | 5.65 |
| CHEMBL1683473 | — | Ki | = | 2304.0 | nM | 5.64 |
| CHEMBL1683469 | — | Ki | = | 2459.0 | nM | 5.61 |