Assay Detail
Functional
CHEMBL1686429
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Anticancer activity against human SKOV3 cells by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure based design of heat shock protein 90 inhibitors acting as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.42 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1683848 | — | — | 1 | 4.84 |
| CHEMBL1683853 | — | — | 1 | 4.77 |
| CHEMBL1683852 | — | — | 1 | 4.46 |
| CHEMBL1683856 | — | — | 1 | 4.41 |
| CHEMBL1683849 | — | — | 1 | 4.21 |
| CHEMBL1683857 | — | — | 1 | 4.16 |
| CHEMBL1683850 | — | — | 1 | 4.12 |
| CHEMBL1683851 | — | — | 1 | - |
| CHEMBL1683854 | — | — | 1 | - |
| CHEMBL1683855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1683848 | — | IC50 | = | 14590.0 | nM | 4.84 |
| CHEMBL1683853 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL1683852 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1683856 | — | IC50 | = | 38830.0 | nM | 4.41 |
| CHEMBL1683849 | — | IC50 | = | 61550.0 | nM | 4.21 |
| CHEMBL1683857 | — | IC50 | = | 69980.0 | nM | 4.16 |
| CHEMBL1683850 | — | IC50 | = | 76030.0 | nM | 4.12 |
| CHEMBL1683851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1683854 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1683855 | — | IC50 | > | 100000.0 | nM | - |