Assay Detail
Functional
CHEMBL1686838
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Cytotoxicity against human COLO205 cells after 72 hrs by MTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.94 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684075 | — | — | 1 | 9.00 |
| CHEMBL1615025 | TAK-733 | 2.0 | 1 | 8.68 |
| CHEMBL1684070 | — | — | 1 | 8.59 |
| CHEMBL1684074 | — | — | 1 | 8.46 |
| CHEMBL1684072 | — | — | 1 | 8.43 |
| CHEMBL1684067 | — | — | 1 | 8.10 |
| CHEMBL1684073 | — | — | 1 | 8.05 |
| CHEMBL1684069 | — | — | 1 | 8.00 |
| CHEMBL1681812 | — | — | 1 | 8.00 |
| CHEMBL1684071 | — | — | 1 | 7.89 |
| CHEMBL1684062 | — | — | 1 | 7.80 |
| CHEMBL1684063 | — | — | 1 | 7.57 |
| CHEMBL1684064 | — | — | 1 | 7.42 |
| CHEMBL1684068 | — | — | 1 | 7.42 |
| CHEMBL1684061 | — | — | 1 | 7.42 |
| CHEMBL1684060 | — | — | 1 | 7.31 |
| CHEMBL1684065 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684075 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1615025 | TAK-733 | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1684070 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1684074 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1684072 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1684067 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL1684073 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1684069 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1681812 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1684071 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1684062 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1684063 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1684064 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1684068 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1684061 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1684060 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1684065 | — | EC50 | = | 142.0 | nM | 6.85 |