Assay Detail
Binding
CHEMBL1686899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus enoyl-ACP reductase assessed as increase of NADPH level
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (CHEMBL3994) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.02 | 5.22 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682259 | PHELLINSTATIN | — | 2 | 5.22 |
| CHEMBL1682260 | HYPHOLOMINE B | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682259 | PHELLINSTATIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1682260 | HYPHOLOMINE B | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1682259 | PHELLINSTATIN | Inhibition | - | % | - |