Assay Detail
Binding
CHEMBL1686970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human vasopressin V2 receptor
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | - | - |
| Ki | 1 | 6.49 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL582857 | NELIVAPTAN | 2.0 | 1 | 6.49 |
| CHEMBL1684573 | — | — | 1 | - |
| CHEMBL1684574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL582857 | NELIVAPTAN | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL1684573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1684574 | — | IC50 | > | 100000.0 | nM | - |