Assay Detail
Functional
CHEMBL1687002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta3 adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.49 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684585 | — | — | 1 | 9.01 |
| CHEMBL1684583 | — | — | 1 | 8.39 |
| CHEMBL1684584 | — | — | 1 | 8.08 |
| CHEMBL1684578 | — | — | 1 | 7.96 |
| CHEMBL1684577 | — | — | 1 | 7.82 |
| CHEMBL1684581 | — | — | 1 | 7.09 |
| CHEMBL1684582 | — | — | 1 | 5.88 |
| CHEMBL1684580 | — | — | 1 | 5.69 |
| CHEMBL1684579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684585 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL1684583 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1684584 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1684578 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1684577 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1684581 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1684582 | — | EC50 | = | 1307.0 | nM | 5.88 |
| CHEMBL1684580 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1684579 | — | EC50 | - | — | - |