Assay Detail
Binding
CHEMBL1687154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 11-hydroxylase activity in Sprague-Dawley rat adrenal gland
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Adrenal gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.28 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682900 | — | — | 2 | 7.89 |
| CHEMBL1682904 | — | — | 1 | - |
| CHEMBL1682905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682900 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1682900 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1682904 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1682905 | — | IC50 | > | 1000.0 | nM | - |