Assay Detail
Functional
CHEMBL1687231
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Cytotoxicity against human HT-29 cells after 2 days by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.53 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684607 | — | — | 1 | 6.41 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.09 |
| CHEMBL1684594 | — | — | 1 | 6.08 |
| CHEMBL1684593 | — | — | 1 | 6.07 |
| CHEMBL1684606 | — | — | 1 | 5.98 |
| CHEMBL1684613 | — | — | 1 | 5.87 |
| CHEMBL1684616 | — | — | 1 | 5.87 |
| CHEMBL1684605 | — | — | 1 | 5.74 |
| CHEMBL1684603 | — | — | 1 | 5.53 |
| CHEMBL1684612 | — | — | 1 | 5.52 |
| CHEMBL1684596 | — | — | 1 | 5.47 |
| CHEMBL1684595 | — | — | 1 | 5.47 |
| CHEMBL1684609 | — | — | 1 | 5.39 |
| CHEMBL1684604 | — | — | 1 | 5.36 |
| CHEMBL1684600 | — | — | 1 | 5.35 |
| CHEMBL1684601 | — | — | 1 | 5.22 |
| CHEMBL1684598 | — | — | 1 | 5.17 |
| CHEMBL1684610 | — | — | 1 | 5.03 |
| CHEMBL1684602 | — | — | 1 | 4.99 |
| CHEMBL533658 | — | — | 1 | 4.91 |
| CHEMBL1684599 | — | — | 1 | 4.62 |
| CHEMBL1684608 | — | — | 1 | - |
| CHEMBL1684611 | — | — | 1 | - |
| CHEMBL1684597 | — | — | 1 | - |
| CHEMBL1684614 | — | — | 1 | - |
| CHEMBL1684615 | — | — | 1 | - |
| CHEMBL1681818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684607 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1684594 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1684593 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1684606 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1684613 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1684616 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1684605 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1684603 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL1684612 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL1684596 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL1684595 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL1684609 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL1684604 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL1684600 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL1684601 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL1684598 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL1684610 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL1684602 | — | IC50 | = | 10290.0 | nM | 4.99 |
| CHEMBL533658 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL1684599 | — | IC50 | = | 23930.0 | nM | 4.62 |
| CHEMBL1684608 | — | IC50 | - | — | - | |
| CHEMBL1684611 | — | IC50 | - | — | - | |
| CHEMBL1684597 | — | IC50 | - | — | - | |
| CHEMBL1684614 | — | IC50 | - | — | - | |
| CHEMBL1684615 | — | IC50 | - | — | - | |
| CHEMBL1681818 | — | IC50 | - | — | - |